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The monthly precipitation data from 29 synoptic stations for the period 1946–2012 were analyzed using a number of different multivariate statistical analysis methods to investigate the spatial variability and temporal patterns of precipitation across Serbia. R-mode principal component analysis was used to study the spatial variability of the precipitation. Three distinct sub-regions were identified by applying the agglomerative hierarchical cluster analysis to the two component scores: C1 includes the north and the northeast part of Serbia, while C2 includes the western part of Central Serbia and southwestern part of Serbia and C3 includes central, east, south and southeast part of Serbia. The analysis of the identified sub-regions indicated that the monthly and seasonal precipitation in sub-region C2 had the values above average, while C1 and C3 had the precipitation values under average. The analysis of the linear trend of the mean annual precipitation showed an increasing trend for the stations located in Serbia and three sub-regions. From the result of this analysis, one can plan land use, water resources and agricultural production in the region.