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Land-cover change in the conterminous United States was quantified by interpreting change from satellite imagery for a sample stratified by 84 ecoregions. Gross and net changes between 11 land-cover classes were estimated for 5 dates of Landsat imagery (1973, 1980, 1986, 1992, and 2000). An estimated 673,000km²(8.6%) of the United States’ land area experienced a change in land cover at least one time during the study period. Forest cover experienced the largest net decline of any class with 97,000km² lost between 1973 and 2000. The large decline in forest cover was prominent in the two regions with the highest percent of overall change, the Marine West Coast Forests (24.5% of the region experienced a change in at least one time period) and the Eastern Temperate Forests (11.4% of the region with at least one change). Agriculture declined by approximately 90,000km² with the largest annual net loss of 12,000km²yr⁻¹ occurring between 1986 and 1992. Developed area increased by 33% and with the rate of conversion to developed accelerating rate over time. The time interval with the highest annual rate of change of 47,000km²yr⁻¹ (0.6% per year) was 1986–1992. This national synthesis documents a spatially and temporally dynamic era of land change between 1973 and 2000. These results quantify land change based on a nationally consistent monitoring protocol and contribute fundamental estimates critical to developing understanding of the causes and consequences of land change in the conterminous United States.