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Land degradation is perceived worldwide as a key process of resource depletion, representing a paradigmatic issue in national and supra-national political agendas for the 21st century in both advanced and emerging economies. Trying to delineate a ‘new lexicon of land degradation’, the present study contributes to a holistic thinking of driving forces in local communities and regional contexts through a refined analysis and discussion of (apparent and latent) factors of land degradation. Rethinking the importance of five notions (time, space, scale, systems, and response) having an intimate linkage with land degradation allows a refined understanding of socio-environmental dynamics and the most appropriate actions to combat (or mitigate) land resource depletion. The conclusions summarize the rationale proposed in this work, and provide a brief outlook on future research addressing land degradation, its drivers and consequences.