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Land cover is closely related to environmental changes and socioeconomic development. Land-cover change in the Tibetan Plateau (TP) is different from that in the lowlands; however, a detailed land-cover change in areas such as the Yarlung Tsangpo River (YTR) basin in the TP has not been reported. To fill this gap, the current study explores the land-cover change between 1985 and 2005 in the YTR basin. The results show that only 1 % of the land cover in the YTR basin changed during this time period. The most significant land-cover changes included increases in forest and built-up areas as well as decreases in grassland, water and wetland areas. By percentage, the most rapid land-cover change occurred for built-up areas with an annual variation of 2.07 %. There was an obvious vertical distribution pattern for land-cover types in the YTR basin; from low to high, the average altitudes were forest, farmland, built-up, grassland, water and wetland, and bare land. The average altitude and slope for most land-cover types did not vary over the past 20 years. However, the average altitude and slope of built-up significantly decreased, especially in the zone between 3,500 and 4,000 m. The water and wetland area in altitudes above 4,500 m increased; however, they decreased in the zone between 3,500 and 4,000 m. Natural factors cause most land-cover changes, whereas the increasing intensity of human activities cause some changes to built-up and farmland. Additional attention should be paid to the study of the mechanism of land-cover change in the TP.